• The objective of the present work

  2019-11-25

  

  The objective of the present work is to search for the optimum blend when 12.5–50% metakaolin is substituted by RHA and reacted with 10 M sodium hydroxide solution to produce geopolymers. It was hypothesized that the amorphous WIN 18446 from RHA will increase the Si/Al ratio of the mix and in situ

• Another interesting finding from the present study is that

  2019-11-25

  

  Another interesting finding from the present study is that silencing of ERRγ suppressed the expression of HSD17B1 in extravillous trophoblasts. HSD17B1 is a key enzyme in regulating estrogen activity and has been shown to promote the proliferation and migration of estrogen-dependent breast cancer Me

• The mechanisms by which Cav enhances embryonal tumor

  2019-11-25

  

  The mechanisms by which Cav-1 enhances embryonal tumor progression are currently unknown. Given the documented ability of Cav-1 to drive increased biogenesis of caveolae and accelerate the flow of nutrients (mostly glucose and fatty acids) across the membrane, as observed in particular in adipocytes

• Stable carbon and nitrogen isotope ratios in bone collagen a

  2019-11-22

  

  Stable carbon and nitrogen isotope ratios in bone collagen and carbon isotope ratios in bone apatite data were obtained by the means of the techniques described in supplementary data (SD1). For collagen, standard indicators have been used to assess its preservation, such as collagen yield, carbon an

• The aim of the present study

  2019-11-22

  

  The aim of the present study was to investigate the acute effects of THC on resting state PD 123319 ditrifluoroacetate neurophysiology, and to examine the impact of COMT genotype on these effects. Thirty-nine healthy volunteers participated in a randomised, placebo-controlled, crossover pharmacologi

• This study focused on NPC L because it

  2019-11-22

  

  This study focused on NPC1L1 because it is critical for intestinal pyk2 of both dietary and biliary cholesterol.1, 7, 8 Overall, regulation in the intestine of cholesterol, BAs, and lipids by FGF19 and SHP may involve the combined actions of regulation of other genes that were identified in our inte

• Enhanced oxidative stress has been suggested

  2019-11-22

  

  Enhanced oxidative stress has been suggested as the critical mechanisms of IS-produced muscle damage [41,42]. NAC as a direct reactive oxygen species ROS scavenger is frequently discussed in the clinical trials of radiocontrast-induced AKI prevention [43]. Despite some supportive epidemiological dat

• CYP A and CYP D are among the

  2019-11-22

  

  CYP3A4/5 and CYP2D6 are among the main drug-metabolizing enzymes in humans that are responsible for the metabolism of more than 50% of marketed drugs [19], [21]. Drugs metabolized by CYPs are prone to drug–drug interactions, thereby modifying their response [18], [32]. Metabolic inhibition is also i

• How does APC C recognize its substrates

  2019-11-22

  

  How does APC/C recognize its substrates and catalyze their ubiquitylation? How are the outcomes and timing of these activities regulated? These questions have driven a decade of structural studies that begin to explain how APC/C interacts with coactivators, substrates, and E2s, and how these interac

• br Conflict of interest br Acknowledgements The authors

  2019-11-22

  

  Conflict of interest Acknowledgements The authors are grateful to laboratory technician Kristina Andersson for expert technical assistance. The authors acknowledge the Swedish Research Council (Grant no. 6834), Region Skåne and Faculty of Medicine, Lund University, for financial support. In

• We initially identified four putative Egr

  2019-11-22

  

  We initially identified four putative Egr1 Nilvadipine sale (−39/−36, −105/−102, −107/−104, and −227/−224) on the DBH proximal promoter. The deletion and mutagenesis experiments indicate that the motif at −227/−224 is required for Egr1-elicited reduction in DBH promoter activity. It remains to be d

• Introduction The inflammation process involves sequential ac

  2019-11-22

  

  Introduction The inflammation process involves sequential activation of signaling molecules, pro-inflammatory mediators, such as prostaglandins, leukotrienes, and oxygen free radicals [1]. Two cyclooxygenases stavudine were responsible for activation of the production of prostaglandins (PG1s) and

• We have previously reported the characterization of

  2019-11-22

  

  We have previously reported the characterization of A-127722, a novel, non-peptide endothelin antagonist that displays very high affinity binding (K=69 pM) with a more than 1000-fold greater affinity for human endothelin ETA than ETB receptor. Although A-127722 is >1000-fold more selective for endot

• A possible explanation for these observations has been provi

  2019-11-22

  

  A possible explanation for these observations has been provided by a recent study showing that EWS-FLI-1 increases the Skp2-mediated 26S proteasome degradation, decreasing p27 protein stability and preventing cell senescence [42]. Mechanism of action of EWS-FLI-1 Molecular analysis has revealed

• Here we report for the first time

  2019-11-22

  

  Here, we report for the first time that EphB4 contains two NLS sequences and localises to the nucleus. This is mediated via an importin-α pathway and we show that EphB4 could potentially have a direct role in gene regulation. These data provide new insight into Eph receptor localisation and action a

15522 records 917/1035 page Previous Next First page 上5页 916917918919920 下5页 Last page