• br Radiotherapy for bone metastases As a palliative

  2019-04-19

  

  Radiotherapy for bone metastases As a palliative intervention, radiotherapy is effective and efficient at treating painful bone metastases, and the side effects associated with its use are manageable and usually self-limiting in nature. Between 50% and 80% of patients gain at least partial relief

• Editorial opinion piece Many patients with advanced cancer w

  2019-04-19

  

  Editorial/opinion piece Many patients with advanced cancer will develop bone metastases and associated complications, including severe pain and debilitating skeletal-related events (SREs), which require radiotherapy, surgery or changes to antineoplastic regimens [1–3]. Fortunately, there are effect

• br Introduction Magnetic resonance imaging MRI

  2019-04-19

  

  Introduction Magnetic resonance imaging (MRI) has great utility in evaluating musculoskeletal tumors. However, some lesions have an appearance on MRI that make it challenging to differentiate benign from malignant lesions. Even intravenous (IV) melanin sometimes does not allow differentiation of

• Certainly dynamic interactions between DTCs and stromal

  2019-04-19

  

  Certainly, dynamic interactions between DTCs and stromal hepititis b within the bone microenvironment disrupt bone homeostasis, which is normally tightly controlled, to fuel metastatic progression [18] (Table 1). For example, it is well established that osteolytic breast cancer DTC-derived factors,

• Seg n el coeficiente de Gini que

  2019-04-19

  

  Según el coeficiente de Gini que mide la desigualdad, en la región es de 0.51, nivel de desigualdad sustancialmente más alto que otras zonas del mundo, al tener en cuenta que Estados Unidos tiene 0.378 y los países de la ocde 0.313. De ahí que el promedio simple de los valores en América Latina indi

• Regarding the expression of NKp NCR Fig A and

  2019-04-18

  

  Regarding the expression of NKp46/NCR1 (Fig. 1A and B), both increased and decreased expression are observed depending on patients. Interestingly, the expression of the inducible molecule NKp44/NCR2 is clearly induced in 3 patients (PT1, PT2 and PT5) both regarding the percentage and the MFI. In con

• We have recently investigated the

  2019-04-18

  

  We have recently investigated the role of the p38 MAPK pathway in heat shock-, osmotic shock-, or microwave irradiation-induced neurite outgrowth of PC12m3 hdac inhibitor [[16], [17], [18]]. When cultures of PC12m3 cells were exposed to heat and osmotic stress or microwave irradiation, activity of

• palbociclib br Case At the time of admission the patient

  2019-04-18

  

  Case At the time of admission, the patient\'s heart rate was irregular with an average rate of 76beats per minute (bpm) (Fig. 1). Her ECG showed sinus rhythm conducted with left-bundle branch block (LBBB) and associated with multiple ectopic premature ventricular beats (PVBs). The PVBs were relat

• br Conclusion br Conflict of

  2019-04-18

  

  Conclusion Conflict of interest Case report A 65-year-old woman with permanent atrial fibrillation was admitted with diastolic lenvatinib failure (HF) secondary to rapid ventricular response. She had undergone single chamber pacemaker implantation (Boston Scientific Ingenio SR) two years e

• In a case similar to ours presented

  2019-04-18

  

  In a case similar to ours, presented by Seres et al. [14] in which LVNC was associated with polymorphic VT, the value of QT interval was also difficult to ascertain because of the advanced LBBB. The onset of the polymorphic VT was similar to ours, but neither pause-dependence nor post-PVB lengthenin

• The incidences of AF and AT

  2019-04-18

  

  The incidences of AF and AT have been shown to be relatively high after minimally invasive AF surgery [18–20]. Edgerton et al. [18] demonstrated that resperidone cost freedom from AF or AT should be assessed by long-term monitoring. Kron et al. [19] showed that 40% of patients could undergo bilater

• Depending on the target gene KLF

  2019-04-18

  

  Depending on the target gene, KLF4 may function as both a repressor and activator of transcription [31,32]. Previous studies demonstrated Bax could be a tumor-suppressor target of KLF4 functioning as an anti-oncogene [33,34]. When transfected with anti-miR-367, MG-63 and U2OS olopatadine hcl cost s

• br Interpretation of identified genetic

  2019-04-18

  

  Interpretation of identified genetic variants and genetic counseling Although the current expert consensus statement recommends that comprehensive or BrS1 (SCN5A) targeted BrS genetic testing can be useful for genetic testing [63], not all the published SCN5A mutations in BrS have been subjected

• Introduction The Yoga My Heart Study was a single

  2019-04-17

  

  Introduction The Yoga My Heart Study was a single center study that brought to light the therapeutic impact a noninvasive, medication-free intervention has on a costly disease. Atrial fibrillation (AF) is a common cardiac arrhythmia that affects two to three million people worldwide. It is associat

• br In their Comment on the use of

  2019-04-17

  

  In their Comment on the use of antenatal corticosteroids to reduce preterm infant deaths, Kishwar Azad and Anthony Costello advise “extreme caution” before scale-up in low-income settings. They emphasise maternal sepsis as a concern but cite only one trial in which dexamethasone resulted in a sign

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