• Post translational modifications of the GR can alter

  2022-04-12

  

  Post-translational modifications of the GR can alter the transcriptional effects of GR activation [31], and may provide a mechanism for the interactions between cell signaling pathways and GR-mediated transcriptional activity. Dex-BSA treatment reportedly increased p38 MAPK activation in CD14-positi

• Introduction Parkinson s Disease PD is a neurodegenerative d

  2022-04-12

  

  Introduction Parkinson's Disease (PD) is a neurodegenerative disease affecting approximately 5–6 million individuals worldwide [1]. This number is expected to escalate to ∼10 million by the year 2030 as the world's population rapidly ages [2]. In the United States, more than 1 million individuals h

• One important discovery of our study is the identification

  2022-04-12

  

  One important discovery of our study is the identification of a pharmacological mechanism for the macrolide antibiotic erythromycin (EM) in promoting joint health. EM is a commonly used antibiotic that directly binds bacterial ribosomes to inhibit protein synthesis [66]. Although EM-like macrolide N

• Further we examined the degradation of Cx Autophagy and

  2022-04-12

  

  Further, we examined the degradation of Cx43. Autophagy and the proteasome system have previously been implicated in Cx43 degradation (Falk et al., 2014). DEX inhibited communication between n acetylneuraminic acid receptor by promoting the degradation of Cx43 through autophagy in osteocytes (Gao e

• Moreover after the initial bleaching of the fluorescent mole

  2022-04-12

  

  Moreover, after the initial bleaching of the fluorescent molecules in the targeted cell exposed to laser illumination, the neighboring reservoir 5416 are expected to give in return new fluorescent ones if the cells are coupled together by gap junction channels. This supposes that the level of fluor

• Single cell reverse transcriptase PCR on A mellifera antenna

  2022-04-12

  

  Single-cell reverse transcriptase-PCR on A. mellifera antennal lobe (AL) cells showed the expression of RDL as well as another GABA receptor like subunit, LCCH3 (Dupuis et al., 2010). Based on whole cell patch-clamp electrophysiology it was concluded that the predominant GABA receptors in AL cells a

• br Acknowledgement We like to thank

  2022-04-12

  

  Acknowledgement We like to thank the Austrian Federal Ministry of Science, Research and Economy for financial support (GZ402.000/00014-WF/V/6/2016 within the Sino-Austria project) as well as Andrea Szabo and Patricia Haiss for support regarding the drawing of figures and tables. Farnesoid X Re

• We note that zinc speciation

  2022-04-12

  

  We note that zinc speciation at 0 and 2 mol. equiv. of myristate is already markedly different; this means that FFAZn2+ crosstalk is in operation under normal physiological conditions. At present, there are few data to allow tracking of the effects of such physiological crosstalk, although there are

• Thus aldolase catalyzing the reversible reaction of F P

  2022-04-11

  

  Thus, aldolase catalyzing the reversible reaction of F1,6-P2 synthesis is involved in the formation of the glyconeogenic or glycolytic complex, dependently on the physiological state of the cell. In the process of glycogen synthesis, the enzyme not only supplies the substrate for FBPase and desensit

• br Introduction Thrombosis is one of the leading causes of

  2022-04-11

  

  Introduction Thrombosis is one of the leading causes of deaths in the cardiovascular diseases such as myocardial infarction (MI), unstable SC-10 and acute coronary syndrome (ACS) in developed countries [1], [2]. It is estimated that venous thromboembolism (VTE) afflicts about 1 million (1–2 per

• The importance of the histone chaperone function of Hat

  2022-04-11

  

  The importance of the histone chaperone function of Hat1p was highlighted by the recent demonstration that the catalytic activity of Hat1p is not sufficient for its function in vivo. Fusion of a nuclear export signal (NES) to yeast Hat1p effectively excluded the enzyme from the nucleus, with a conco

• br H R agonists In search for potent and selective

  2022-04-11

  

  H2R agonists In search for potent and selective H2R agonists, comprehensive structure–activity relationship studies have been conducted and led to the first H2R agonists, e.g. 4(5)-methylhistamine (16) which is actually now used as selective H4R agonist (Fig. 4) (Durant et al., 1975, Lim et al.,

• Whereas Sororin is dispensable in the absence

  2022-04-11

  

  Whereas Sororin is dispensable in the absence of Wapl [14], overexpressed Haspin only partly supports cohesion in Sororin-depleted cells. Thus, although Haspin and Sororin have functional similarities, they are not fully redundant at the centromere. Haspin may have a mitosis-specific role in maintai

• Previous reports have implicated the

  2022-04-11

  

  Previous reports have implicated the guanylin/GC-C signalling system as being important in osmoregulation in fish, especially in euryhaline species such as the eel which migrate between freshwater (FW) and seawater (SW) environments at different stages of their life cycle (Comrie et al., 2001a, Comr

• The isoenzyme hGSTP is an attractive drug target due to

  2022-04-11

  

  The isoenzyme hGSTP1-1 is an attractive drug target due to its high levels of disease association (target validation) and druggability (target tractability) properties [5,6,[17], [18], [19], [20], [21]]. hGSTP1-1 functions as a homodimer protein [18]. Each monomer has two domains, an α/β domain (N-t

15572 records 447/1039 page Previous Next First page 上5页 446447448449450 下5页 Last page