• integrin inhibitor Acknowledgments br Introduction Diabetes

  2021-01-28

  

  Acknowledgments Introduction Diabetes mellitus (DM) is a multifactorial disease [1] associated with serious comorbidities. This condition has recently reached epidemic proportions, as its occurrence has exponentially increased in the general population. Over 400 million people worldwide were est

• br DNA end processing enzymes

  2021-01-28

  

  DNA end processing enzymes The simplest DSB is one that consists of two blunt DNA ends as these termini can be re-joined without processing. However, DSBs induced by ionizing radiation and reactive oxygen species are notorious for producing DNA ends which are non-ligatable (“dirty ends”) and thus

• The binding of collagen X

  2021-01-28

  

  The binding of collagen X to DDR2 differs from the binding of collagen X to α2β1 integrin in that the triple helical conformation is essential for DDR2 binding. We previously reported that heat denatured pepsinised collagen X supported cell adhesion via α2β1, indicating that the triple-helical confo

• The excitatory amino acid L glutamate or glutamate mediates

  2021-01-28

  

  The excitatory amino BRD-9424 L-glutamate or glutamate mediates most of the excitatory neurotransmission within the mammalian central nervous system (CNS) and has been implicated in numerous peripheral nervous system (PNS) pathways. The excitatory amino acids, including glutamate, are of great phys

• br Conclusion br Acknowledgements br Introduction

  2021-01-27

  

  Conclusion Acknowledgements Introduction In recent years, fast progress has been made toward using the supercritical technology in industrial separation processes. Apart from a green extraction process that replaces organic solvents, applications involving supercritical fluids include super

• br Material and methods br

  2021-01-27

  

  Material and methods Results Discussion Isolated telaprevir have several potential advantages over other in-vitro approaches, such as expression of properties similar to their site of origin including the possibility of bidirectional transmembrane transport and exposure. Furthermore, they

• Across the scaffold the platform anchors the

  2021-01-27

  

  Across the scaffold, the platform anchors the N terminus of the elongated cullin structure of APC2 [21]. This connects to the flexible cullin–RING catalytic core consisting of the C-terminal region of APC2 and the associated APC11 11, 12, 21. The flexibility and positions of the catalytic core are c

• cyclosporin Addressing whether impaired activation of D and

  2021-01-27

  

  Addressing whether impaired activation of D1 and D2 receptors regulates memory capacity is relevant for all human pathologies that lead to reduced activation of these cyclosporin pathways, such as ageing [39], certain genetic polymorphisms [40] and neurodegenerative disorders. In this study, we hav

• Primary human GBM neurospheres expressed high levels

  2021-01-27

  

  Primary human GBM neurospheres expressed high levels of the metabolic enzyme fatty acyl-CoA synthetase VL3 (ACSVL3) that were associated with CSCs self-renewal and tumorigenic capacity. ACSVL3 knockdown significantly decreased ALDH levels, indicating its contribution to cell metabolism and maintenan

• br Cyclin dependent kinases control more than cell cycle

  2021-01-27

  

  Cyclin-dependent kinases control more than cell cycle CDKs’ roles conducting the concert of BEC was first revealed in the context of the tumor suppressor Rb, phosphorylation of which by CDK4 or CDK6 inactivates it loosing the transcription factor E2F [1], [12], [15]. Discovery of other cyclin/CD

• br Acknowledgments The authors thank Elisabete Lepera and

  2021-01-27

  

  Acknowledgments The authors thank Elisabete Lepera and Rosana Silva for technical support. The study was supported by FAPESP, CNPq and PADC/FCF-UNESP. T.T. Miguel was the recipient of a FAPESP (Proc. 05/05171-1) and R.L. Nunes-de-Souza of a CNPq (Proc. 303580/2009-7) fellowship. Introduction

• It is of interest to point

  2021-01-27

  

  It is of interest to point out that curcumin in this study reduced body weight gain; the underlying mechanism may be due to a decrease in general hyPerFUsion™ high-fidelity PCR Kit of fat, which was associated with a significantly reduced NPC1L1 expression in small intestine. Labonte et al revealed

• Considering these reports and with the aim

  2021-01-26

  

  Considering these reports, and with the aim of further investigating the mechanism by which the cAMP-Epac/PKA pathway activates eNOS, we have performed imaging experiments evaluating the effect of drugs that increase cAMP or modify its signalling pathways (PKA or Epac activators and inhibitors) on b

• To elucidate whether the impact of hypoxia

  2021-01-26

  

  To elucidate whether the impact of hypoxia on EGFR expression is cell context specific or culturing density dependent, we chose the following cancer hesperetin driven by EGFR and evaluated the EGFR expression after hypoxia treatment at different culturing density: a highly aggressive and poorly dif

• In the SUMOylation pathway SCE

  2021-01-26

  

  In the SUMOylation pathway, SCE1 as an E2 enzyme has an important role in mediating the conjugation of SUMO to target proteins. The accumulated SUMO conjugates in plants are associated with abiotic stress responses (Castro et al, 2012). We performed a drought stress analysis on WT plants, induced by

15176 records 679/1012 page Previous Next First page 上5页 676677678679680 下5页 Last page