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br Materials and methods br Results br Discussion
2020-08-03
Materials and methods Results Discussion Field populations of the P. xylostella pest have evolved various levels of resistance to 95 active ingredients (APRD, 2018), including abamectin (Pu et al., 2010) and fipronil (Wang et al., 2016b) pesticides that act on GluCls. We previously identifi
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We aimed to evaluate optical
2020-08-03
We aimed to evaluate optical control with BACCS as a simple method to regulate osteoblast differentiation without further physical and biochemical treatment. Spatiotemporal control of Ca2+ signaling may facilitate intracellular interrogation of osteogenesis and extend the application of BACCS to phy
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br Regulation of DGK activity Activation of
2020-08-03
Regulation of DGK activity Activation of the DGKs is complex and unique for each DGK isotype. In most cases, DGKs must translocate to a membrane compartment to access DAG. However, translocation does not necessarily activate the enzyme [57]. In addition, DGK activity can be modified by other cofa
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Since these first results KSTD activity
2020-08-03
— Since these first results, Δ1-KSTD activity has been identified in many other microorganisms, albeit sometimes with different substrate preferences. For instance, Comamonas testosteroni ATCC 11996 (formerly Pseudomonas testosteroni) is active on several steroid substrates, but it cannot use 11β-h
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The observed increase in oxidative stress
2020-07-31
The observed increase in oxidative stress was also associated with decreased migration of cells as well as 96365 disturbances. The migration of PNT1A cells was significantly decreased after both ZEA and ZEA+PHTPP treatments in two highest concentrations and correlated with the decreased ZEB2 express
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PF-573228 The cervix undergoes complex changes during the no
2020-07-31
The PF-573228 undergoes complex changes during the normal estrous cycle, pregnancy and parturition (Nallasamy and Mahendroo, 2017). During estrus in the ewe and mouse, there is slight relaxation and dilation which is partly due to the reorganization of collagen bundles and fibers that disperse and
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N6-Cyclopentyladenosine br Cytochrome P monooxygenases Cytoc
2020-07-31
Cytochrome P450 monooxygenases Cytochrome P450 monooxygenases (P450s) belong to one of Nature’s most versatile group of enzymes for C–H functionalization and are able to perform challenging regioselective and stereoselective activations of remote, unactivated C(sp3)–H bonds, for which there are o
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Previously we showed that MS a combined extract of
2020-07-31
Previously, we showed that MS-10, a combined extract of Cirsium japonicum var. Maackii (Maxim.) Matsum. (Korean milk thistle) and Thymus vulgaris L., increases the efficiency of estrogen in the estrogen-deficient state by activating the estrogen receptor (ER). MS-10 increased bone mineral density (B
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In addition to proteasome the UPP also includes ubiquitin
2020-07-31
In addition to proteasome, the UPP also includes ubiquitin, ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), ubiquitin ligases (E3s) and deubiquitinases (DUBs), which collectively work in three discrete and successive steps: 1) the substrate is tagged by the covalent attachme
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Moving forward there are several factors that should
2020-07-31
Moving forward, there are several factors that should be considered. First, dopamine release differs between striosome and matrix compartments of the striatum, and cocaine enhances dopamine to a greater extent in DStr striosomes compared to matrix (Salinas et al., 2016). Since dopamine release is co
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ptc124 Besides chemopreventive effects against oxidative
2020-07-31
Besides chemopreventive effects against oxidative DNA damage we evaluated the protective effects of the three Hypericum sp. and isolated compounds against alkylating DNA damage induced by MMS in HT29 cells. Human exposure to alkylating agents, from different sources, occurs in a continuous way and i
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It is generally thought that the nature
2020-07-31
It is generally thought that the nature of a memorial and the meaning attributed to it Alsterpaullone receptor by a tourist determines, at least in part, the behaviour that is socially appropriate (Mayo, 1988). Duncan (1995) argues however, that certain places are structured in such a way that they
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As stated above the limited number of
2020-07-31
As stated above, the limited number of proven CMV pneumonia cases in our series precluded any attempt to establish a diagnostic CMV DNA load cutoff; nevertheless, in light of the data presented herein, a threshold value of 500 IU/ml is unlikely to be discriminative between CMV pneumonia and pulmonar
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br Introduction DNA ligation is required during DNA replicat
2020-07-30
Introduction DNA ligation is required during DNA replication and to complete almost all DNA repair events. In human cells, the DNA ligases encoded by three LIG genes are responsible for joining interruptions in the phosphodiester backbone [1]. These enzymes have distinct but overlapping functions
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br Acknowledgements This work was financially supported by
2020-07-30
Acknowledgements This work was financially supported by the Natural Science Foundation of Jiangsu Province (BK20180857), General Program of Natural Science Foundation of the Higher Education Institutions of Jiangsu Province (17KJB150009) and China Postdoctoral Science Foundation Funded Project (2
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